Beilstein J. Org. Chem.2018,14, 2545–2552, doi:10.3762/bjoc.14.231
target enzyme by a dual binding site mechanism whereby the coumarin portion binds with the peripheral anionic site while the N-benzylpyridinium residue binds with the catalytic anionic site of the enzyme.
Keywords: acetylcholinesterase inhibitor; 3-aminocoumarin; N-benzylpyridinium; dualbindingsite
inhibitor; synthesis; Introduction
An increasing number of countries are facing a rapid growth of the elderly population. The birth rates of many countries, such as China, Japan, and Thailand are lower than the number theoretically required for the replacement of successive generations, resulting in an